泰国矽肺发病和抗结核免疫力关系的探讨Study on Thailand tuberculosis immunity and silicosis relationship 摘要:（摘要内容经过系统自动伪原创处理以避免复制，下载原文正常，内容请直接查看目录。） Objective The first and foremost purpose of this study was to investigate the morbidity of silicosis and pulmonary tuberculosis among stone grinding workers and to discoverthe related risk factors that could proliferate the morbidity of silicosis and pulmonary tuberculosis。Secondly， this research aimedto investigate the relationship between TB immunity and silicosis incidence through comparison between the case and control groups who had TB immunity and non一TB immunity， and to study the reaction time among silicosis cases who had TB immunity and non一TB immunity， after exposure to the silica dust (SiO2)。 Methodology Radiograph pattern indicated the silicosis cases or the control group and sex， age and working area matched controls。 The sputum analysis by acid一fast staining， polymerase chain reaction and culture confirmed pulmonary tuberculosis (TB)。 The reaction of tuberculin skin testing without TB disease was immunity criteria。 In addition， the dust samples were analyzed to determine the dust concentration and the content of SiO2%。 Results The results showed that during 1995一2001 the silicosis incidence was 16。9， 17。0， 7。1， 20。7， 13。2 and 17。1 per 1000， respectively。 According to monitoring record， the highest respirable dust concentration was 9。35 mg/m3 (SD=10。08) and the content of SiO2 was 6。47% (SD=9。32) that was 50 per cent exceeding threshold limit value (TLV)。 The highest silicosis incidence was 56。3 per 1000 in the south region and the incidence of increment was significantly associated with the higher dust concentration。 The incidence of pulmonary tuberculosis was 3。7 per 1000 and the highest was 15。1 per 1000 in the northeast region。 For the silicotuberculosis in the central and east regions， the incidence was 0。44 per 1000。 Finally， the related risk factors were studied。 The study found that the prevalence of silicosis was significantly associated with the age， exposure time， year of smoking and lack of PPE usage。 Afterward， it was proved that the risk related factors between case and control groups were not significantly different 。 In addition， the samples’ exposure year (was calculated by multiplying exposure time and dust exposed concentration) and the exposure time， were significantly different between reactive and non一reactive among silicosis and silicotuberculosis groups。 《WP=6》Conclusion The incidence of silicosis in Thailand was constantly at a high level in the last 5 years ranging from 7。1 to 20。7 per 1000 and was obviously due to the high level of silica dust exposure in the working environment。 In addition， the study found that the incidence of pulmonary tuberculosis (PTB) among the risk workers of Thailand was 5。69 per cent that near caused by both Mycobacterium tuberculosis and non Mycobacterium tuberculosis。 Finally， the finding of the study that significantly associated mean of person exposure year and exposure times with tuberculin skin testing result。 However， the skin test usually use for screening case。 So the high accuracy investigation method still need more for taking together and leading to the strongly summary service program later。 The results suggested that there is a need for developing a national database for silicosis and pulmonary tuberculosis among stone grinding workers and executing a medical surveillance and a national occupational medical。 Abstract: 目的本探讨的首要目的是调查磨石工人和发现相关危险因素能形成矽肺和肺结核的发病率矽肺和肺结核的发病率。其次，本探讨的目的在于研讨结核病免疫和矽肺发病率通过比较病例组和对照组之间有结核病的免疫和非一结核病免疫，并探讨矽肺例结核病免疫和非一结核病免疫之间的反应时间，暴露于二氧化硅（SiO2）粉尘后。措施X线模式表明矽肺病例和对照组性别、年龄、工作区配套有限控制。通过酸一快速染色痰液略论、聚合酶链反应和培养证实的肺结核（TB），无结核病结核菌素皮肤测试反应的免疫标准。此外，粉尘样品进行了略论测定的粉尘浓度和SiO2 %的含量。结果表明，在1995一2001矽肺发病率为16.9，17，7.1，20.7，13.2和17.1每1000，分别根据监测记录，最高的呼吸性粉尘浓度为9.35毫克/立方米（SD = 10.08）和SiO2的含量为6.47%（SD = 9.32），占比为50超过阈限值（TLV）。矽肺发病率最高，为56。3每1000在南方地区发病率的增加明显与高粉尘浓度有关。肺结核的发病率为3.7每1000，最高是15.1每1000在东北地区，在中部和东部地区的矽肺结核，发病率为0.44／1000。最后，进行了探讨相关危险因素。探讨发现，矽肺患病率与年龄明显相关的曝光时间，吸烟和缺乏个人防护有关的一年。后来，证明了风险的相关因素，病例组和对照组之间没有显著异同。此外，样品暴露年（计算穆尔tiplying曝光时间和接触粉尘浓度）和曝光时间，泰语专业论文，为反应性和非反应一矽肺和矽肺结核组间异同显著。《WP = 6》结论泰国矽肺的发病率在不断的在过去的5年中从7.1到20.7每1000个高水平，显然是由于在工作环境粉尘暴露水平高。此外，探讨发现，肺结核的发病率（PTB）风险泰国工人占比为5.69，接近由结核分枝杆菌和非结核分枝杆菌引起的。最后，泰语毕业论文，本探讨认为显著相关意味着世博会找人确定年曝光结核菌素皮肤试验结果的时代。然而，通常使用皮肤测试屏幕 目录: |
