作 者:Joon-Ho Keum (11448) ; Ok-Hwa Kang (11448) (21448) ; Sung-Bae Kim (11448) ; Su-Hyun Mun (11448) ; Yun-Soo Seo (11448) ; Ma-Ryong Kim (11448) ; Jung-Rae Rho (21448) ; Young-Seob Lee (31448) ; Chung-Berm Park (31448) ; Young-Guk Kim (31448) ; Yong-Il Kim (31448) ; sin-Hee Han (31448) ; Dong-Yeul Kwon (11448) ; 机构地区: 出 处:《中国结合医学杂志:英文版》2017年第5期380-386,共7页Chinese Journal of Integrative Medicine 基 金:Supported by the National Research Foundation of Korea Grant (No. NRF-2017-013-E00034) and the Grant of the Traditional Korean Medicine R&D project, Ministry of Health & Welfare, Republic of Korea (No. B120179) 摘 要:客观 Cheongseoikki-tang (市民,朝鲜语) ,也叫的 Qingshu Yiqi 煎() 并且 Seisho-ekki-to (日语) ,作为为治疗心血管的疾病的植物的有效传统的联合众所周知。这探讨是在骨头上探讨它的效果导出髓的桅杆房间(BMMC ) 调停了过敏症和发炎机制。在这的措施学习, Cheongseoikki-tang 乙醇摘录的生物效果(引用) 被评估,加钙 ionophore A23187 (A23187 ) 由 phorbol 12 十四酸盐 13 醋酸盐(PMA ) 在过敏调停人的生产上集中于它的效果刺激了 BMMC。这些过敏调停人包括的 interleukin-6 (IL-6 ) ,日语论文,前列腺素 D2 (PGD2 ) ,日语论文, leukotriene C4 (LTC4 ) ,和 -hexosaminidase (-hex) 。我们的数据揭示了的结果引用禁止了 PMA 正 A23187 导致的 IL-6, PGD2, LTC4,和十六进制的生产(P < 0.05 ) 。结论这些调查结果显示那引用在过敏症的处理为使用有潜力。Objective: Cheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction(清署益气汤)and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms. Methods: In this study, the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myfistate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included intedeukin-6 (IL-6), prostaglandin D2 (PGD2), leukotfiene (34 (LTC4), and β-hexosaminidase (13-hex). Results: Our data revealed that CITE inhibited the production of IL-6, PGD2,/TC4, and 15-hex induced by PMA plus A23187 (P〈0.05). Conclusion: These findings indicate that CITE has the potential for use in the treatment of allergy. 关 键 词:过敏性反应 乙醇提取物 肥大细胞 钙离子载体 前列腺素D2 分 类 号:S432.23[农业科学—植物病理学;农业科学—农业昆虫与害虫防治;农业科学—植物保护] TS202.3[轻工技术与工程—食品科学;轻工技术与工程—食品科学与工程] |