In this , I would like to give a definition of genetic engineering firstly. And then, the disciplines that contribute to the genetic engineering will be introduced, too. Each technology that human created is to serve the people. So, I would like to introduce some examples of the applications of genetic engineering currently and historically, as well as the types of genetic engineering .And I will provide some examples of potential advances in genetic engineering. Lastly, the effects of genetic engineering have on us and the whole world will be concluded. Genetic Engineering What is genetic engineering? Genetic engineering, also called the genetic modification, is to manipulate an organism’s genome by using biotechnology. By synthesizing the DNA and then inserting it into the host organism, or insert new DNA in the host organism by first isolation and copying the genetic material of interest, the genes may be removed. Or they will just be knocked out[1]. And the IUPAC also define genetic engineering as Process of inserting new genetic information into existing cells in order to modify a specific organism for the purpose of changing its characteristics[2]. Disciplines That Contributes To Genetic Engineering The modern genetic engineering includes many different disciplines such as molecularbiology, biochemistry, genetics, cellbiology, embryology, immunology, organic chemistry physical chemistry, physical, information science, computer science. It’s common that a new technology can contain so many disciplines, cause that all most no technology is independent. With the development of the researches of other disciplines, the genetic engineering developed so quickly .And also it is technology which is related to materials like DNA, RNA, chromosome, genome, heredity, mutation and so on. Historic and current applications of transgenic biotechnology Looking back the history of genetic engineering, we maybe surprised that this kind of technology firstly developed in agrarian age. Back in the ancient time, our ancestors began to use this kind of technology to select seeds. And it is the pioneer of transgenic biotechnology. The farmers select and bred the best suited crops which have the highest yields to produce more food to feed the growing population. As crops became difficult to maintain, people discovered that specific organisms and their by-products could effectively fertilize. And the farmers are clover enough to breed one plant to other plants. For example, the Chinese people altered the genetics of their apple tree by breeding them with other plants such as the plum trees, which was one of the first forms of transgenic biotechnology. However, It was in 1970s that humans began the direct manipulation of DNA out side breeding and mutations. In 1951,Jack Williamson first coined the term Genetic Engineering in his science fiction novel called Dragon's Island. In 1972 Paul Berg combined DNA from monkey virus SV40 with that of the lambda virus, and so, he created the first recombinant DNA. In 1974,Rudolf Jaenisch created the first transgenic animal by introducing foreign DNA its embryo[3]. The first genetic engineering company was founded by Herbert Boyer and Robert Swanson ,which is called Genentech. And a year later, the company produced a human protein. In 1995,after having been approved by the FDA, Bt Potato was approved by Environment Protection Agency. And another thing to say is that in 2017,transgenic crops grown in 25countries such an China, Brazil, India and Canada. In 2017,It was announced that the scientists had created the first synthetic genome, which was added to a cell that contained no DNA. Now, the scientists are making efforts to do more experiments to achieve more.[4] Types Of Genetic Engineering Genetic engineering is used mainly in four areas, including health care, crops and agriculture, environmental uses and the non food uses of crops and other products. And the health care and agriculture are closely linked to our daily life. Health Care, The Medicine Modern Genetic engineering applied in medicine care is mainly in areas such as pharmaceutical drug, genetic screening and pharmacogenomics. Pharmacogenomics is the combination of pharmacology and genomics, and it analyses the effect a genetic makeup has on an individual’s response to drugs by correlating gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity. And modern genetic engineering contributes a lot to the manufacturing of traditional small molecule pharmaceutics drugs. And it also makes it available to manufacture existing medicines cheaply and easily. To cite an example, diabetes was thought as a incurable disease, because insulin was hard to produce and so, it’s relatively expensive. However, In 1978,when Genentech firstly developed a synthetic humanized insulin, things changed to be different. He joined the gene of the insulin with a plasmid vector and inserted the new gene into the bacterium Escherichia coli. In this way, he achieved the manufacture of insulin and makes it easier and cheaper to cure diabetes. |
